Paul Kosma,Sven Müller-Loennies's Anticarbohydrate Antibodies: From Molecular Basis to PDF

By Paul Kosma,Sven Müller-Loennies

ISBN-10: 3709108691

ISBN-13: 9783709108697

ISBN-10: 3709148359

ISBN-13: 9783709148358

Many pathogens and aberrant malignant cells show specified carbohydrates on their floor representing beautiful ambitions for vaccine layout. huge growth has lately been made within the id of novel carbohydrate established vaccines and a multitude has reached medical section experiences. The luck of a number of authorized carbohydrate dependent vaccines opposed to bacterial pathogens equivalent to Haemophilus influenzae kind b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their nice capability. in spite of the fact that, the learn of anti-carbohydrate antibodies is technically demanding and partially as a result of low affinities and promiscuous specificity they've got now not been medically exploited to complete power. The examine of antibody specificities and id of protecting carbohydrate epitopes lies on the middle of winning vaccine layout. as well as treatment, antibodies normally function diagnostic instruments in scientific and medical laboratories. during this environment excessive affinity and delightful specificity are very important elements for his or her winning use. “Anticarbohydrate Antibodies – from molecular foundation to scientific program” compiles present wisdom at the immunological popularity of carbohydrates via the adaptive immune method from a molecular standpoint offering basic perception wanted for advancing clinically appropriate diagnostics and healing functions. in keeping with major development within the fields of glycoimmunology and structural biology lately, the publication comprehensively stories the cutting-edge in defining the most important parts of carbohydrate acceptance by means of antibodies, the molecular mimicry of carbohydrate epitopes in addition to the molecular positive aspects resulting in particular and cozy binding modes. Backed-up through a mix of recent applied sciences to clarify structural information of carbohydrate-antibody interactions, biomedically vital carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells were analyzed in in-depth experiences written by way of famous specialists within the box. primary wisdom of those molecular mechanisms finally presents a rational foundation to enhance efficacy of carbohydrate-based vaccines and to extra refine diagnostic instruments in detection of pathogens and malignant cells.

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Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application by Paul Kosma,Sven Müller-Loennies

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